A novel therapeutic peptide targeting myocardial reperfusion injury
نویسندگان
چکیده
منابع مشابه
Targeting Myocardial Reperfusion Injury--The Search Continues.
Timely reperfusion by means of primary percu taneous coronary intervention (PCI) is the most effective therapy for limiting myocardial infarct size in patients with STsegment elevation myo cardial infarction (STEMI). Although mortality in this patient population is falling, the number of patients in whom heart failure develops is increasing. As such, new treatments are needed to reduce myoca...
متن کاملMyocardial ischemia-reperfusion injury: a neglected therapeutic target.
Acute myocardial infarction (MI) is a major cause of death and disability worldwide. In patients with MI, the treatment of choice for reducing acute myocardial ischemic injury and limiting MI size is timely and effective myocardial reperfusion using either thombolytic therapy or primary percutaneous coronary intervention (PPCI). However, the process of reperfusion can itself induce cardiomyocyt...
متن کاملSuccinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Myocardial ischaemia/reperfusion (IR) injury is a major cause of death worldwide and remains a disease for which current clinical therapies are strikingly deficient. While the production of mitochondrial reactive oxygen species (ROS) is a critical driver of tissue damage upon reperfusion, the precise mechanisms underlying ROS production have remained elusive. More recently, it has been demonstr...
متن کاملMyocardial Reperfusion Injury
Around the world, and especially in the Western Society, cardiovascular diseases remain one of the leading causes of death.(1) Within the broad range of cardiovas-cular diseases, the proportional burden of ischemic heart disease is especially high within the Middle East, North America, Australia, and the majority of Europe.(2) In the Netherlands, cardiovascular diseases have been the leading ca...
متن کاملTherapeutic effects of 1,25-dihydroxyvitamin D and losartan co-administration on myocardial ischemia-reperfusion injury in rats
Introduction: Studies support the idea that low levels of vitamin D are associated with a higher risk of heart disease. Losartan has also been prescribed as a drug commonly used for treating hypertension. The aim of the current study was to investigate the effects of 1,25-dihydroxyvitamin D in combination with a non-hypotensive dose of losartan on myocardial infarct size, reperfusion-induced...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2019
ISSN: 0008-6363,1755-3245
DOI: 10.1093/cvr/cvz145